Explore scientific evidence
about non-invasive ventilation
with high-flux generator
in different areas of application

WHO Global. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. World Health Organization 2020.
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Mc Enery T et al. COVID-19: Respiratory support outside the intensive care unit. Lancet Respir Med 2020. Available online 9 April 2020.
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Nishkantha A. Use of non-invasive ventilation for patients with COVID-19: a cause for concern? Lancet Respir Med 2020. Published Online April 20, 2020.
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Longhini F et al. High-Flow Oxygen Therapy After Noninvasive Ventilation Interruption in Patients Recovering From Hypercapnic Acute Respiratory Failure: A Physiological Crossover Trial. Crit Care Med. 2019 Jun;47(6):e506-e511.
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Spoletini G et al. High-flow nasal therapy vs standard oxygen during breaks off noninvasive ventilation for acute respiratory failure: A pilot randomized controlled trial. J Crit Care. 2018 Dec;48:418-425.
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Mauri T et al. Nasal High Flow: Physiology, Efficacy and Safety in the Acute Care Setting, a Narrative Review. Open Access Emerg Med. 2019 May 29;11:109-120.
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Möller W et al. Nasal high flow clears anatomical dead space in upper airway models. J Appl Physiol (1985). 2015 Jun 15;118(12):1525-32. J Appl Physiol (1985). 2013 Apr;114(8):1058-65.
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Mündel T et al. Mechanisms of nasal high flow on ventilation during wakefulness and sleep. J Appl Physiol (1985). 2013 Apr;114(8):1058-65.
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Ni YN et al. Can high-Flow Nasal Cannula Reduce the Rate of Reintubation in Adult Patients After Extubation? A Meta-Analysis. BMC Pulm Med. 2017 Nov 17;17(1):142.
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Ni YN et al. The Effect of High-Flow Nasal Cannula in Reducing the Mortality and the Rate of Endotracheal Intubation When Used Before Mechanical Ventilation Compared With Conventional Oxygen Therapy and Noninvasive Positive Pressure Ventilation. A Systematic Review and Meta-Analysis. Am J Emerg Med. 2018 Feb;36(2):226-233.
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Spoletini G et al. Heated Humidified High-Flow Nasal Oxygen in Adults: Mechanisms of Action and Clinical Implications. Chest. 2015 Jul;148(1):253-261.
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Van Hove SC et al. An Experimental and Numerical Investigation of CO2 Distribution in the Upper Airways During Nasal High Flow Therapy. Ann Biomed Eng. 2016 Oct;44(10):3007-3019.
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Goligher EC & Slutsky AS. Not Just Oxygen? Mechanisms of Benefit from High-Flow Nasal Cannula in Hypoxemic Respiratory Failure. Am J Respir Crit Care Med. 2017 May 1;195(9):1128-1131.
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Ni YN et al. Can High-flow Nasal Cannula Reduce the Rate of Endotracheal Intubation in Adult Patients With Acute Respiratory Failure Compared With Conventional Oxygen Therapy and Noninvasive Positive Pressure Ventilation?: A Systematic Review and Meta-analysis. Chest. 2017 Apr;151(4):764-775.
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Rochwerg E et al. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J. 2017 Aug 31;50(2):1602426.
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Biselli PJC. Nasal high-flow therapy reduces work of breathing compared with oxygen during sleep in COPD and smoking controls: a prospective observational study. J Appl Physiol (1985). 2017 Jan 1;122(1):82-88.
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Cortegiani A et al. High-flow nasal therapy versus noninvasive ventilation in COPD patients with mild-to-moderate hypercapnic acute respiratory failure: study protocol for a noninferiority randomized clinical trial. Trials. 2019 Jul 22;20(1):450. doi: 10.1186/s13063-019-3514-1.
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Pisani L et al. Change in Pulmonary Mechanics and the Effect on Breathing Pattern of High Flow Oxygen Therapy in Stable Hypercapnic COPD. Thorax. 2017 Apr;72(4):373-375.
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Pisani L & Vega ML. Use of Nasal High Flow in Stable COPD: Rationale and Physiology. COPD. 2017 Jun;14(3):346-350.
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Pisani L et al. Effects of High-Flow Nasal Cannula in Patients With Persistent Hypercapnia After an Acute COPD Exacerbation: A Prospective Pilot Study. BMC Pulm Med. 2020 Jan 13;20(1):12.
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Storgaard LH. Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure. Int J Chron Obstruct Pulmon Dis. 2018 Apr 16;13:1195-1205.
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