Explore scientific evidence
about non-invasive ventilation
with high-flux generator
in different areas of application

WHO Global. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. World Health Organization 2020.
Download PDF
Mc Enery T et al. COVID-19: Respiratory support outside the intensive care unit. Lancet Respir Med 2020. Available online 9 April 2020.
Download PDF
Nishkantha A. Use of non-invasive ventilation for patients with COVID-19: a cause for concern? Lancet Respir Med 2020. Published Online April 20, 2020.
Download PDF
KEY ADVANTAGES OF NON INVASIVE VENTILATORS (NIV)
Read
Longhini F et al. High-Flow Oxygen Therapy After Noninvasive Ventilation Interruption in Patients Recovering From Hypercapnic Acute Respiratory Failure: A Physiological Crossover Trial. Crit Care Med. 2019 Jun;47(6):e506-e511.
Read the abstract
Spoletini G et al. High-flow nasal therapy vs standard oxygen during breaks off noninvasive ventilation for acute respiratory failure: A pilot randomized controlled trial. J Crit Care. 2018 Dec;48:418-425.
Read the abstract
M.L. Vega, L.Pisani Nasal high flow oxygen in acute respiratory failure
Download PDF
Mauri T et al. Nasal High Flow: Physiology, Efficacy and Safety in the Acute Care Setting, a Narrative Review. Open Access Emerg Med. 2019 May 29;11:109-120.
Download PDF
Möller W et al. Nasal high flow clears anatomical dead space in upper airway models. J Appl Physiol (1985). 2015 Jun 15;118(12):1525-32. J Appl Physiol (1985). 2013 Apr;114(8):1058-65.
Download PDF
Mündel T et al. Mechanisms of nasal high flow on ventilation during wakefulness and sleep. J Appl Physiol (1985). 2013 Apr;114(8):1058-65.
Download PDF
Ni YN et al. Can high-Flow Nasal Cannula Reduce the Rate of Reintubation in Adult Patients After Extubation? A Meta-Analysis. BMC Pulm Med. 2017 Nov 17;17(1):142.
Download PDF
Ni YN et al. The Effect of High-Flow Nasal Cannula in Reducing the Mortality and the Rate of Endotracheal Intubation When Used Before Mechanical Ventilation Compared With Conventional Oxygen Therapy and Noninvasive Positive Pressure Ventilation. A Systematic Review and Meta-Analysis. Am J Emerg Med. 2018 Feb;36(2):226-233.
Read the abstract
Spoletini G et al. Heated Humidified High-Flow Nasal Oxygen in Adults: Mechanisms of Action and Clinical Implications. Chest. 2015 Jul;148(1):253-261.
Read the abstract
Van Hove SC et al. An Experimental and Numerical Investigation of CO2 Distribution in the Upper Airways During Nasal High Flow Therapy. Ann Biomed Eng. 2016 Oct;44(10):3007-3019.
Read the abstract
Goligher EC & Slutsky AS. Not Just Oxygen? Mechanisms of Benefit from High-Flow Nasal Cannula in Hypoxemic Respiratory Failure. Am J Respir Crit Care Med. 2017 May 1;195(9):1128-1131.
Download PDF
Ni YN et al. Can High-flow Nasal Cannula Reduce the Rate of Endotracheal Intubation in Adult Patients With Acute Respiratory Failure Compared With Conventional Oxygen Therapy and Noninvasive Positive Pressure Ventilation?: A Systematic Review and Meta-analysis. Chest. 2017 Apr;151(4):764-775.
Read the abstract
Rochwerg E et al. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J. 2017 Aug 31;50(2):1602426.
Download PDF
Biselli PJC. Nasal high-flow therapy reduces work of breathing compared with oxygen during sleep in COPD and smoking controls: a prospective observational study. J Appl Physiol (1985). 2017 Jan 1;122(1):82-88.
Download PDF
Cortegiani A et al. High-flow nasal therapy versus noninvasive ventilation in COPD patients with mild-to-moderate hypercapnic acute respiratory failure: study protocol for a noninferiority randomized clinical trial. Trials. 2019 Jul 22;20(1):450. doi: 10.1186/s13063-019-3514-1.
Download PDF
Pisani L et al. Change in Pulmonary Mechanics and the Effect on Breathing Pattern of High Flow Oxygen Therapy in Stable Hypercapnic COPD. Thorax. 2017 Apr;72(4):373-375.
Download PDF
Pisani L & Vega ML. Use of Nasal High Flow in Stable COPD: Rationale and Physiology. COPD. 2017 Jun;14(3):346-350.
Read the abstract
Pisani L et al. Effects of High-Flow Nasal Cannula in Patients With Persistent Hypercapnia After an Acute COPD Exacerbation: A Prospective Pilot Study. BMC Pulm Med. 2020 Jan 13;20(1):12.
Download PDF
Storgaard LH. Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure. Int J Chron Obstruct Pulmon Dis. 2018 Apr 16;13:1195-1205.
Download PDF

Contact us to learn more about Biorespira

Please provide the following information and we will get back to you quickly with more information on your request.

Type of request: